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Structural analysis of the designed multi‐epitope vaccine construct. (A) The best generated 3D structure of the vaccine construct from GalaxyRefine color‐mapped by the order of peptide arrangement. (B) Z‐score graph predicted from the ProSA‐server. (C) Ramachandran plot analysis profiling the position of the vaccine′s <t>amino</t> <t>acid</t> residues in the favored, allowed, and disallowed regions. (D) Secondary structure analysis of the vaccine construct predicted by PSIPRED. (E) Generated solubility graph of the vaccine construct from the <t>Protein‐Sol</t> database.
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Structural analysis of the designed multi‐epitope vaccine construct. (A) The best generated 3D structure of the vaccine construct from GalaxyRefine color‐mapped by the order of peptide arrangement. (B) Z‐score graph predicted from the ProSA‐server. (C) Ramachandran plot analysis profiling the position of the vaccine′s amino acid residues in the favored, allowed, and disallowed regions. (D) Secondary structure analysis of the vaccine construct predicted by PSIPRED. (E) Generated solubility graph of the vaccine construct from the Protein‐Sol database.

Journal: Health Science Reports

Article Title: Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐ Causing Malaria: A Computational Approach

doi: 10.1002/hsr2.71353

Figure Lengend Snippet: Structural analysis of the designed multi‐epitope vaccine construct. (A) The best generated 3D structure of the vaccine construct from GalaxyRefine color‐mapped by the order of peptide arrangement. (B) Z‐score graph predicted from the ProSA‐server. (C) Ramachandran plot analysis profiling the position of the vaccine′s amino acid residues in the favored, allowed, and disallowed regions. (D) Secondary structure analysis of the vaccine construct predicted by PSIPRED. (E) Generated solubility graph of the vaccine construct from the Protein‐Sol database.

Article Snippet: In this study, the protein amino acid sequences were submitted to the Immune Epitope Database (IEDB) web server at http://tools.iedb.org , to predict MHC class I and II peptide binding epitopes.

Techniques: Construct, Generated, Solubility